Crystal structure of 4-(1-mesityl-1-methylcyclobutane-3-yl)-2-(N-ethyl)aminothiazole.

attracted the attention of chemists, since they exhibit important biological activity in medicinal chemistry.1 As one example, they show very good antibacterial effects.2 Here, we report the crystal structure of the title compound, shown in Fig. 1. To a solution of 1.042 g (10 mmol) of N-ethyl thiourea in 50 mL of absolute ethanol, a solution of 2.645 g (10 mmol) of 1-mesityl-1-methyl-3-(2-chrloro-1oxoethyl)cyclobutane, which was synthesized according to the published procedure,3 in 20 mL of absolute ethanol was added dropwise at 60 – 70 ̊C with continuous stirring and monitoring the course of reaction with IR. Monitoring the visibility of the carbonyl group of 1 mesityl-1-methyl-3-(2-chloro-1oxoethyl)cyclobutane is easily done and so it is very easy to determine the completion of the reaction. After the reaction had completed, the solution was made alkaline with an aqueous solution of NH3 (5%) to separate a pale yellow solid substance, 4-(1-mesityl-1-methylcyclobutane-3-yl)-2-(N-ethyl)aminothiazole. The precipitate was filtered off, washed with aqueous ammonia solution and water several times, dried in air and crystallized from aqueous ethanol (1:3). Thus, beautiful diffraction quality shining crystals of the substance were obtained. The authenticity of the substance was first established 725 ANALYTICAL SCIENCES JUNE 2002, VOL. 18 2002 © The Japan Society for Analytical Chemistry